PA5-29645 targets Arginase I in WB and IHC-P applications and shows reactivity with Human, Rat and mouse samples.
The PA5-29645 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 175 of Human Arginase I.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
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Protein Aliases: AI type I arginase; arginase 1, liver; arginase I; arginase, liver; Arginase-1; Liver-type arginase; Type I arginase
Gene Aliases: AI; AI256583; Arg-1; ARG1; PGIF
Molecular Function: hydrolase