This antibody is expected to react with equine (91%), bovine and rabbit (90%), porcine (83%), ovine, goat and canine (81%) based on sequence homology.
Suggested positive control: antigen standard for CYP19A1 (transient overexpression lysate), human Fetal Temporal Lobe protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Aromatase; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; cytochrome P450 family 19 subfamily a; Cytochrome P450, 19, aromatase; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, subfamily 19; cytochrome P450, subfamily XIX (aromatization of androgens); Estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; P-450AROM
Gene Aliases: Ar; ArKO; ARO; ARO1; Arom; Aromatase; CPV1; CYAR; CYP19; Cyp19a; CYP19A1; CYPXIX; Int-5; Int5; P-450AROM; p450arom
Molecular Function: oxygenase