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Fabgennix
Aurora A Polyclonal Antibody, FITC
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Product Details
AURKA-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 350-397 on human Aurora Kinase A protein.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment. Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AURAK; aurora 2; aurora A; Aurora A Kinase; aurora family kinase 1; aurora-A; aurora-related kinase 1; aurora/IP; aurora/IPL1-related kinase 1; AURORA2; EC 2.7.11.1; hARK1; IAK1; ipl1- and aurora-related kinase 1; IPL1-related kinase; MGC34538; OTTHUMP00000031341; OTTHUMP00000166072; protein kinase; ratAurA; RP5-1167H4.6; serine/threonine kinase 6; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase Ayk1; STK6; aurora-A; IPL1-related kinase; AIK; BTAK; STK15; unnamed protein product
Gene Aliases: AIRK1; ARK-1; Ark1; Aurora-A; Ayk1; IAK; IAK1; Stk6
UniProt ID: (Mouse) P97477
Entrez Gene ID: (Rat) 261730, (Mouse) 20878
meiotic spindle organization
microtubule cytoskeleton organization
mitotic cell cycle
chromatin remodeling
protein phosphorylation
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
centrosome cycle
mitotic centrosome separation
response to wounding
anterior/posterior axis specification
negative regulation of gene expression
peptidyl-serine phosphorylation
regulation of protein stability
response to estradiol
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cytokinesis
negative regulation of apoptotic process
positive regulation of translation
positive regulation of mitotic cell cycle
meiotic cell cycle
centrosome localization
cilium disassembly
protein localization to centrosome
positive regulation of mitochondrial fission
liver regeneration
positive regulation of oocyte maturation
positive regulation of meiotic cell cycle process involved in oocyte maturation
neuron projection extension
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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