Synthetic peptide sequence: 109-125aa, QKTEDTKKRQWTLEDFD.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Aurora A is a 46 kDa protein that plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Multiple transcript variants encoding the same protein have been found for this gene. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal.
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Protein Aliases: 220.127.116.11; Aik, Airk, Ark1, Aura, Ayk1, Btak, Iak1, Stk15, Stk6; ARK-1; Aurka; Aurora 2; aurora A; Aurora family kinase 1; Aurora kinase A; aurora-A; aurora-related kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; ratAurA; serine/threonine kinase 6; serine/threonine protein kinase 6; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase Ayk1
Gene Aliases: Aik; Airk; AIRK1; ARK-1; Ark1; AU019385; Aura; Aurka; Aurora-A; AW539821; Ayk1; Btak; IAK; IAK1; Stk15; Stk6
UniProt ID: (Mouse) P97477