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Invitrogen
Axl Polyclonal Antibody
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FIGURE: 1 / 2
Axl Antibody (PA5-14567) in IHC (P)
Immunohistochemistry analysis of Axl in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Axl polyclonal antibody (Product # PA5-14567) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatoca... View More
Product Details
PA5-14567
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 863-894 amino acids from the C-terminal region of human AXL
Conjugate
Form
Liquid
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AXL oncogene; AXL transforming sequence/gene; AZF1; oncogene AXL; putative tyrosine kinase receptor; sAXL; soluble AXL; Tyrosine-protein kinase receptor UFO; unnamed protein product
Gene Aliases: ARK; AXL; AXL3; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530
Entrez Gene ID: (Human) 558
neuron migration
natural killer cell differentiation
negative regulation of cytokine production
positive regulation of cytokine-mediated signaling pathway
blood vessel remodeling
immune system process
phagocytosis
apoptotic process
inflammatory response
signal transduction
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
nervous system development
positive regulation of signal transduction
negative regulation of macrophage cytokine production
cell migration
forebrain cell migration
cell differentiation
platelet activation
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of natural killer cell differentiation
secretion by cell
erythrocyte homeostasis
substrate adhesion-dependent cell spreading
cellular response to interferon-alpha
ovulation cycle
negative regulation of apoptotic process
apoptotic cell clearance
negative regulation of neuron apoptotic process
innate immune response
lymphocyte activation
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
cell maturation
positive regulation of pinocytosis
regulation of lymphocyte activation
negative regulation of lymphocyte activation
neuron apoptotic process
establishment of localization in cell
positive regulation of protein kinase B signaling
vagina development
cellular response to lipopolysaccharide
dendritic cell differentiation
neutrophil clearance
mononuclear cell differentiation
positive regulation of viral life cycle
negative regulation of dendritic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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