Keep as concentrated solution.
Positive Control: A549, H1299, HCT116, PC-12.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
B-raf belongs to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in the gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 94 kDa B-raf protein; 94 kDa B-raf protein antibody; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene serine/threonine-protein kinase (p94) antibody; B-RAF1 antibody; BRAF antibody; BRAF1 antibody; FLJ95109 antibody; MGC126806 antibody; MGC138284 antibody; murine sarcoma viral (v-raf) oncogene homolog B1; murine sarcoma viral (v-raf) oncogene homolog B1 antibody; NS7 antibody; p94; p94 antibody; Proto-oncogene B-Raf; proto-oncogene B-Raf antibody; RAFB1 antibody; Serine/threonine-protein kinase B-raf; serine/threonine-protein kinase B-raf antibody; v-raf murine sarcoma viral oncogene homolog B; v-Raf murine sarcoma viral oncogene homolog B1; v-raf murine sarcoma viral oncogene homolog B1 antibody
Gene Aliases: 9930012E13Rik; AA120551; AA387315; AA473386; B-raf; B-RAF1; BRAF; Braf-2; BRAF1; Braf2; C230098H17; C87398; D6Ertd631e; NS7; RAFB1