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FIGURE: 1 / 1
Positive test controls include: Mouse kidney, Rat thymus. The target is usually found in the following locations: Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein.
Immunogen sequence: VGAIQEIPKA KEFMANFHKT LILGKGKTLT NEASTKKVEL DNCPSVSPYL RGQSKLIFKP DLTLEEVQAE NPKVSRGRYR PQECKALQRV AILVPHRNRE KHLMYLLEHL HPFLQRQQLD YGIYVIHQAE GKKFNRAKLL NVGYLEALKE ENWDCFIFHD VDLVPENDFN LYKCEEHPKH LVVGRNSTGY RLRYSGYFGG VTALSREQFF KVNGFSNNYW GWGGEDDDLR LRVELQRMKI SRPLPEVGKY TMVFHTRDKG NEVNAERMKL LHQVSRVWRT DGLSSCSYKL VSVEHNPLYI NITVDFWFGA
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
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