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Proteintech
BACE1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-12807
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BACE1 fusion protein Ag3559
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VRANIAAIT ESDKFFINGS NWEGILGLAY AEIARPDDSL EPFFDSLVKQ THVPNLFSLQ LCGAGFPLNQ SEVLASVGGS MIIGGIDHSL YTGSLWYTPI RREWYYEVII VRVEINGQDL KMDCKEYNYD KSIVDSGTTN LRLPKKVFEA AVKSIKAASS TEKFPDGFWL GEQLVCWQAG TTPWNIFPVI SLYLMGEVTN QSFRITILPQ QYLRPVEDVA TSQDDCYKFA ISQSSTGTVM GAVIMEGFYV VFDRARKRIG FAVSACHVHD EFRTAAVEGP FVTLDMEDCG YNIPQTDEST LM
Target Information
BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE-1B; BACE-1C; BACE-1D; BACE-I-432; BACEdelta7; Beta secretase; Beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP processing enzyme; beta-site APP-cleaving enzyme; beta-site APP-cleaving enzyme 1; Memapsin; Memapsin-2; Memapsin2; membrane type aspartyl protease; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; unnamed protein product
Gene Aliases: ASP2; BACE; BACE1; C76936; HSPC104; KIAA1149; zgc:77409
UniProt ID: (Human) P56817, (Rat) P56819, (Mouse) P56818
Entrez Gene ID: (Human) 23621, (Rat) 29392, (Mouse) 23821, (Zebrafish) 403005
proteolysis
membrane protein ectodomain proteolysis
response to lead ion
protein processing
beta-amyloid formation
amyloid precursor protein catabolic process
positive regulation of neuron apoptotic process
beta-amyloid metabolic process
modulation of synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
prepulse inhibition
cellular response to copper ion
cellular response to manganese ion
presynaptic modulation of chemical synaptic transmission
signaling receptor ligand precursor processing
cellular response to beta-amyloid
amyloid fibril formation
protein catabolic process
myelination in peripheral nervous system
positive regulation of myelination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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