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Proteintech
BAF170 Polyclonal Antibody
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Product Details
12018-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BAF170 Fusion Protein Ag2634 (300-647 aa encoded by BC013045)
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Amount
111 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRSPSPSPT PEAKKKNAKK GPSTPYTKSK RGHREEEQED LTKDMDEPSP VPNVEEVTLP KTVNTKKDSE SAPVKGGTMT DLDEQEDESM ETTGKDEDEN STGNKGEQTK NPDLHEDNVT EQTHHIIIPS YAAWFDYNSV HAIERRALPE FFNGKNKSKT PEIYLAYRNF MIDTYRLNPQ EYLTSTACRR NLAGDVCAIM RVHAFLEQWG LINYQVDAES RPTPMGPPPT SHFHVLADTP SGLVPLQPKT PQGRQVDADT KAGRKGKELD DLVPETAKGK PELQTSASQQ MLNFPDKGKE KPTDMQNFGL RTDMYTKKNV PSKSKAAASA TREWTEQETL LLLEALEMY (300-647 aa encoded by BC013045)
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAF170; BRG1-associated factor 170; chromatin remodeling complex BAF170 subunit; DKFZp313D0632; mammalian chromatin remodeling complex BRG1-associated factor 170; similar to SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c2; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3-like protein; unnamed protein product
Gene Aliases: 5930405J04Rik; BAF170; CRACC2; CSS8; Rsc8; SMARCC2
UniProt ID: (Human) Q8TAQ2, (Mouse) Q6PDG5
Entrez Gene ID: (Rat) 685179, (Human) 6601, (Mouse) 68094
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
DNA binding
chromatin binding
protein binding
nucleosomal DNA binding
transcription coactivator activity
histone binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
ATP-dependent chromatin remodeling
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
chromatin organization
regulation of transcription, DNA-templated
nervous system development
regulation of mitotic metaphase/anaphase transition
positive regulation of T cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
regulation of G0 to G1 transition
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
transcription, DNA-templated
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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