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Invitrogen
BAP31 Monoclonal Antibody (CC-4)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
MA3-003
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Hamster,
Human,
Non-human primate
Published species
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
CC-4
Immunogen
Amino acid residues 123-229 of human BAP31.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_325096
Product Specific Information
MA3-003 detects BAP31 from human, non-human primate, bovine and hamster samples.
MA3-003 has been successfully used in Western blot, immunofluorescent, and immunohistochemical procedures. By Western blot, this antibody detects a 28-kDa protein corresponding to human BAP31.
The MA3-003 antigen is solubilized protein from human neuroendocrine cell line IMR-32, followed by an extract of the small lung human carcinoma cell line SCC-9. MA3-003 binds to a more proximal region of BAP31 (amino acids 123-229). This sequence is conserved in non-human primate, bovine and hamster species.
Target Information
BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 6C6 antigen; 6C6-AG tumor-associated antigen; B-cell receptor-associated protein 31; BCR-associated protein 31; BCR-associated protein Bap31; CDM protein; OTTHUMP00000025978; p28; p28 Bap31; Protein CDM
Gene Aliases: 6C6-AG; BAP31; BCAP31; CDM; DDCH; DXS1357E
UniProt ID: (Human) P51572
Entrez Gene ID: (Human) 10134, (Bovine) 533949, (Chinese hamster) 100770274
antigen processing and presentation of peptide antigen via MHC class I
intracellular protein transport
ER to Golgi vesicle-mediated transport
cellular component disassembly involved in execution phase of apoptosis
positive regulation of cytosolic calcium ion concentration
spermatogenesis
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrial calcium ion concentration
protein localization to endoplasmic reticulum exit site
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
positive regulation of retrograde protein transport, ER to cytosol
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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