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Invitrogen
BARD1 Polyclonal Antibody
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Product Details
PA5-60850
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BARD1. Recombinant protein control fragment (Product #RP-96098).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MIQLCSKLRN LLHDNELSDL KEDKPRKSLF NDAGNKKNSI KMWFSPRSKK VRYVVSKASV QTQPAIKKDA SAQQDS
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.
Target Information
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BARD 1; BARD-1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
Gene Aliases: BARD1
UniProt ID: (Human) Q99728
Entrez Gene ID: (Human) 580
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
tissue homeostasis
DNA replication
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
cell cycle arrest
protein ubiquitination
negative regulation of mRNA 3'-end processing
regulation of phosphorylation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of protein catabolic process
negative regulation of protein export from nucleus
protein K6-linked ubiquitination
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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