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BCL-RAMBO Polyclonal Antibody
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FIGURE: 1 / 3
BCL-RAMBO Antibody (600-401-Z49) in ICC/IF
Immunofluorescence Microscopy of Bcl-rambo antibody. Cell Type: human heart cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: Bcl-rambo antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: Bcl-rambo is mitochondrial and nuclear. Staining: Bcl-rambo as red fluorescent signal.
Product Details
600-401-Z49
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Bcl-rambo antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human Bcl-rambo.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2-like protein 13; Bcl-rambo; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); MIL1; mitochondria located 1 homolog; Protein Mil1; unnamed protein product
Gene Aliases: BCL-RAMBO; Bcl2-L-13; BCL2L13; CD003; E430016C20Rik; Mil-1; MIL1
UniProt ID: (Human) Q9BXK5, (Mouse) P59017
Entrez Gene ID: (Human) 23786, (Mouse) 94044, (Rat) 312682
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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