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Proteintech
BCL3 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-23959
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCL3 fusion protein Ag21040
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: NLPTPLYPM MCPMEHPLSA DIAMATRADE DGDTPLHIAV VQGNLPAVHR LVNLFQQGGR ELDIYNNLRQ TPLHLAVITT LPSVVRLLVT AGASPMALDR HGQTAAHLAC EHRSPTCLRA LLDSAAPGTL DLEARNYDGL TALHVAVNTE CQETVQLLLE RGADIDAVDI KSGRSPLIHA VENNSLSMVQ LLLQHGANVN AQMYSGSSAL HSASGRGLLP LVRTLVRSGA DSSLKNCHND TPLMVARSRR VIDILRGKAT RPASTSQPDP SPDRSANTSP ESSSRLSSNG LLSASPSSSP SQSPPRDPPG FPMAPPNFFL PSPSPPAFLP FAGVLRGPGR PVPPSPAPGG S
Target Information
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell CLL/lymphoma 3; B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3 protein homolog; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; lymphoma 3-encoded protein (bcl-3); Proto-oncogene BCL3; unnamed protein product
Gene Aliases: AI528691; Bcl-3; BCL3; BCL4; D19S37
UniProt ID: (Human) P20749, (Mouse) Q9Z2F6
Entrez Gene ID: (Human) 602, (Mouse) 12051
transcription cofactor activity
transcription coactivator activity
transcription corepressor activity
protein binding
protein binding, bridging
histone deacetylase binding
DNA-binding transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
membrane traffic protein
negative regulation of cytokine production
follicular dendritic cell differentiation
marginal zone B cell differentiation
humoral immune response mediated by circulating immunoglobulin
germinal center formation
protein import into nucleus
apoptotic process
response to stress
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
response to UV-C
positive regulation of gene expression
antimicrobial humoral response
extracellular matrix organization
DNA damage response, signal transduction by p53 class mediator
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
T-helper 1 type immune response
defense response to bacterium
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
defense response to protozoan
regulation of apoptotic process
negative regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of translation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
spleen development
regulation of DNA binding
response to other organism
T cell apoptotic process
negative regulation of T cell apoptotic process
regulation of NIK/NF-kappaB signaling
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of tumor necrosis factor biosynthetic process
positive regulation of interleukin-10 biosynthetic process
negative regulation of interleukin-8 biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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