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NeoBiotechnologies
BCOR Recombinant Rabbit Monoclonal Antibody (BCOR/13087R)
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Product Details
54880-RBM5-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BCOR/13087R
Immunogen
Recombinant fragment (around aa 100-400) of human BCOR protein (exact sequence is proprietary).
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product cellular localization: Cytoplasm.
Positive control: Colon mucosa: Staining should be strong at the surface and at least moderate at the basis of krypts.
Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
Target Information
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCL-6 corepressor; BCL-6 interacting corepressor; BCoR
Gene Aliases: ANOP2; BCOR; KIAA1575; MAA2; MCOPS2
UniProt ID: (Human) Q6W2J9
Entrez Gene ID: (Human) 54880
negative regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K36 methylation
transcription, DNA-templated
heart development
negative regulation of bone mineralization
histone H2A monoubiquitination
odontogenesis
negative regulation of transcription, DNA-templated
negative regulation of histone H3-K4 methylation
palate development
specification of axis polarity
negative regulation of tooth mineralization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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