Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: basic helix-loop-helix domain containing, class B, 8; basic helix-loop-helix family, member a15; Basic helix-loop-helix transcription factor (bHlH); bHLHa15; bHLHb8; Class A basic helix-loop-helix protein 15; Class B basic helix-loop-helix protein 8; class II bHLH protein MIST1; MIST-1; Muscle, intestine and stomach expression 1
Gene Aliases: 1810009C13Rik; bHlH; BHLHA15; BHLHB8; MIST-1; MIST1
Molecular Function: basic helix-loop-helix transcription factor