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Product Details
A301-004A
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000-1:10,000 | - |
Immunohistochemistry (IHC) |
1:100-1:500 | - |
Immunoprecipitation (IP) |
2-5 µg/mg lysate | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Between 300 and 350 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.20 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
TBS, pH 7.0 to 8.0, with 0.1% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factor guanine nucleotide-exchange factor 2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); Brefeldin A-inhibited GEP 2; Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Gene Aliases: ARFGEF2; ARFGEP2; BIG2; dJ1164I10.1; PVNH2
UniProt ID: (Human) Q9Y6D5
Entrez Gene ID: (Human) 10564
Molecular Function:
guanyl-nucleotide exchange factor
receptor recycling
exocytosis
Golgi to plasma membrane transport
endosome organization
endomembrane system organization
protein transport
regulation of ARF protein signal transduction
positive regulation of tumor necrosis factor production
intracellular signal transduction
positive regulation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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