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Invitrogen
BIN1 Polyclonal Antibody
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Product Details
PA5-51104
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the C-terminal region of human Amphiphysin II.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
BIN1 Polyclonal Antibody detects endogenous levels of BIN1 protein.
Target Information
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMPH 2; Amph2; amphiphysin 2; Amphiphysin II; amphiphysin IIamph2; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; Myc box-dependent-interacting protein 1; SH3 domain-containing protein 9
Gene Aliases: ALP-1; AMPH2; AMPHL; BIN1; BRAMP-2; SH3P9
UniProt ID: (Human) O00499, (Mouse) O08539, (Rat) O08839
Entrez Gene ID: (Human) 274, (Mouse) 30948, (Rat) 117028
endocytosis
multicellular organism development
regulation of endocytosis
cell differentiation
muscle cell differentiation
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of neuron differentiation
positive regulation of endocytosis
positive regulation of astrocyte differentiation
lipid tube assembly
regulation of cell cycle arrest
nucleus organization
cell proliferation
viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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