PA5-27288 targets BMP4 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-27288 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 287 of Human BMP4.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
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Protein Aliases: BMP-2B; BMP-4; BMP2B; BMP2B1; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; MCOPS6; OFC11; ZYME
Gene Aliases: Bmp-4; BMP2B; Bmp2b-1; BMP2B1; BMP4; Dvr-4; DVR4; MCOPS6; OFC11; ZYME