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BMP10 Polyclonal Antibody
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Product Details
BS-9447R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BMP10, amino acids 350-400.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-10; bmp10 {ECO:0000312|EMBL:BAE16990.1, ECO:0000312|RGD:1562986}; Bone morphogenetic protein; Bone morphogenetic protein 10
Gene Aliases: BMP10
UniProt ID: (Human) O95393, (Rat) Q4AEG6, (Mouse) Q9R229
Entrez Gene ID: (Human) 27302, (Rat) 500245, (Mouse) 12154
kidney development
cell adhesion
heart development
adult heart development
negative regulation of endothelial cell migration
regulation of cardiac muscle hypertrophy
positive regulation of cardiac muscle hypertrophy
negative regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of cell growth
negative regulation of cell migration
BMP signaling pathway
activin receptor signaling pathway
sarcomere organization
positive regulation of transcription, DNA-templated
positive regulation of multicellular organismal process
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell development
regulation of cardiac muscle contraction
cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of sarcomere organization
heart trabecula formation
positive regulation of SMAD protein import into nucleus
positive regulation of cartilage development
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cardiac muscle hypertrophy in response to stress
positive regulation of cell proliferation involved in heart morphogenesis
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of apoptotic process
regulation of MAPK cascade
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
multicellular organism development
growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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