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Proteintech
BMP6 Polyclonal Antibody
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Product Details
55421-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
120 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP; BMP 6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; unnamed protein product; vegetal related growth factor (TGFB-related); VG-1-R; VG-1-related protein; VGR-1
Gene Aliases: Bmp-6; BMP6; D13Wsu115e; IO; VGR; VGR1
UniProt ID: (Human) P22004, (Mouse) P20722
Entrez Gene ID: (Human) 654, (Mouse) 12161
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
ossification
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
endochondral ossification
type B pancreatic cell development
cellular iron ion homeostasis
inflammatory response
immune response
heart development
positive regulation of cell proliferation
tissue development
response to iron ion
positive regulation of gene expression
response to activity
cell differentiation
neuron differentiation
positive regulation of bone mineralization
BMP signaling pathway
male genitalia development
positive regulation of lipopolysaccharide-mediated signaling pathway
response to magnesium ion
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
response to retinoic acid
regulation of cell proliferation
positive regulation of vascular permeability
positive regulation of endothelial cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
positive regulation of developmental process
cartilage development
response to glucocorticoid
bone development
positive regulation of SMAD protein import into nucleus
multicellular organismal iron ion homeostasis
cellular response to mechanical stimulus
cellular response to iron ion
cellular response to BMP stimulus
positive regulation of intracellular signal transduction
negative regulation of adherens junction organization
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of aldosterone secretion
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of apoptotic process
regulation of MAPK cascade
SMAD protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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