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Invitrogen
BMPR1A Polyclonal Antibody
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FIGURE: 1 / 15
BMPR1A Antibody (38-6000) in ICC/IF
Immunofluorescent analysis of BMPR1A /CD292 was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with BMPR1A /CD292 Rabbit Polyclonal Antibody (Product # 38-6000) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conju... View More
Product Details
38-6000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from an internal region of the human BMPR-1A (bone morphogenetic protein receptor type 1A, Serine/threonine protein kinase receptor R5 (SKR5), activin receptor-like kinase-3 (ALK-3)), which differs from mouse and rat BMPR-1A by one nonconservative amino acid replacement.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; Bone morphogenetic protein 4 receptor; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5; unnamed protein product
Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK-3; ALK3; AU045487; Bmpr; BMPR-1A; BMPR-IA; BMPR1A; CD292; SKR5
UniProt ID: (Human) P36894, (Rat) Q78EA7, (Mouse) P36895
Entrez Gene ID: (Human) 657, (Rat) 81507, (Mouse) 12166
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
kinase activity
transferase activity
BMP binding
protein homodimerization activity
SMAD binding
metal ion binding
BMP receptor activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
molecular_function
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
glycoprotein binding
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
angiogenesis
osteoblast differentiation
in utero embryonic development
mesoderm formation
somitogenesis
Mullerian duct regression
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
atrioventricular valve development
mitral valve morphogenesis
tricuspid valve morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
endocardial cushion formation
cellular iron ion homeostasis
immune response
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
pattern specification process
ectoderm development
nervous system development
endoderm development
heart development
dorsal/ventral axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
positive regulation of gene expression
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
neural crest cell development
negative regulation of smooth muscle cell migration
central nervous system neuron differentiation
pituitary gland development
neural plate mediolateral regionalization
cell differentiation
lung development
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of transforming growth factor beta2 production
somatic stem cell population maintenance
hindlimb morphogenesis
dorsal aorta morphogenesis
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm development
paraxial mesoderm structural organization
lateral mesoderm development
regulation of lateral mesodermal cell fate specification
mesendoderm development
embryonic organ development
developmental growth
embryonic morphogenesis
stem cell differentiation
epithelial cell proliferation
positive regulation of epithelial cell proliferation
negative regulation of neurogenesis
negative regulation of muscle cell differentiation
cartilage development
palate development
regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
neural plate pattern specification
heart formation
atrioventricular node cell development
pharyngeal arch artery morphogenesis
cellular response to growth factor stimulus
cellular response to BMP stimulus
positive regulation of dendrite development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of cardiac ventricle development
positive regulation of vascular smooth muscle cell proliferation
fibrous ring of heart morphogenesis
regulation of neural crest cell differentiation
anti-Mullerian hormone signaling pathway
regulation of cellular senescence
regulation of endothelial cell proliferation
transcription from RNA polymerase II promoter
protein phosphorylation
biological_process
positive regulation of pathway-restricted SMAD protein phosphorylation
stem cell population maintenance
signal transduction by protein phosphorylation
regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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