Fabgennix

BMPR1A Polyclonal Antibody

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BMPR1A Polyclonal Antibody

Product Details

BMPR1A-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

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Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK3; AU045487; Bmpr; BMPR-IA; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894, (Rat) Q78EA7, (Mouse) P36895

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Entrez Gene ID: (Human) 657, (Rat) 81507, (Mouse) 12166

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity molecular_function transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
in utero embryonic development mesoderm formation somitogenesis Mullerian duct regression positive regulation of mesenchymal cell proliferation chondrocyte differentiation outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation protein phosphorylation immune response transforming growth factor beta receptor signaling pathway ectoderm development dorsal/ventral axis specification regulation of cardiac muscle cell apoptotic process positive regulation of pathway-restricted SMAD protein phosphorylation neural crest cell development negative regulation of smooth muscle cell migration stem cell population maintenance pituitary gland development neural plate mediolateral regionalization signal transduction by protein phosphorylation lung development positive regulation of bone mineralization BMP signaling pathway hindlimb morphogenesis dorsal aorta morphogenesis odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm structural organization lateral mesoderm development regulation of lateral mesodermal cell fate specification mesendoderm development embryonic organ development developmental growth positive regulation of epithelial cell proliferation negative regulation of neurogenesis palate development regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of SMAD protein import into nucleus heart formation pharyngeal arch artery morphogenesis cellular response to BMP stimulus positive regulation of cardiac ventricle development positive regulation of vascular smooth muscle cell proliferation regulation of cellular senescence regulation of endothelial cell proliferation heart morphogenesis transcription from RNA polymerase II promoter pattern specification process nervous system development endoderm development heart development biological_process anterior/posterior pattern specification dorsal/ventral pattern formation cell differentiation regulation of endothelial cell differentiation positive regulation of transcription, DNA-templated paraxial mesoderm development embryonic morphogenesis cartilage development neural plate pattern specification transmembrane receptor protein serine/threonine kinase signaling pathway phosphorylation
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