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BMPR1B Polyclonal Antibody

View all (9) CDw293 antibodies

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BMPR1B Polyclonal Antibody

Product Details

BS-6639R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human BMPR1B, amino acids 61-160.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BMPR1B (also known as ALK6, CDw293) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. BMPR1B is mainly involved in the endochondral bone formation and embryogenesis. BMPR1B expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6; unnamed protein product

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Gene Aliases: Acvrlk6; AI385617; ALK-6; ALK6; AMD3; AMDD; AV355320; BDA1D; BDA2; BMPR-1B; BMPR-IB; BMPR1B; CDw293; CFK-43a; SKR6

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UniProt ID: (Human) O00238, (Mouse) P36898

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Entrez Gene ID: (Human) 658, (Mouse) 12167, (Rat) 310914

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane signaling receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding kinase activity transferase activity BMP binding SMAD binding metal ion binding BMP receptor activity glycoprotein binding receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transferase activity, transferring phosphorus-containing groups molecular_function serine/threonine protein kinase receptor
Process(es)
cartilage condensation ovarian cumulus expansion osteoblast differentiation eye development chondrocyte differentiation chondrocyte development inflammatory response transmembrane receptor protein serine/threonine kinase signaling pathway dorsal/ventral pattern formation positive regulation of gene expression central nervous system neuron differentiation cell differentiation proteoglycan biosynthetic process positive regulation of bone mineralization BMP signaling pathway retinal ganglion cell axon guidance positive regulation of chondrocyte differentiation ovulation cycle camera-type eye development positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter cartilage development retina development in camera-type eye bone development endochondral bone morphogenesis positive regulation of cartilage development cellular response to growth factor stimulus cellular response to BMP stimulus positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of chondrocyte proliferation skeletal system development protein phosphorylation estrogen biosynthetic process transforming growth factor beta receptor signaling pathway phosphorylation limb morphogenesis positive regulation of cell differentiation biological_process signal transduction by protein phosphorylation
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