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BMPR1B Polyclonal Antibody
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Product Details
BS-6639R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BMPR1B, amino acids 61-160.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BMPR1B (also known as ALK6, CDw293) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. BMPR1B is mainly involved in the endochondral bone formation and embryogenesis. BMPR1B expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6; unnamed protein product
Gene Aliases: Acvrlk6; AI385617; ALK-6; ALK6; AMD3; AMDD; AV355320; BDA1D; BDA2; BMPR-1B; BMPR-IB; BMPR1B; CDw293; CFK-43a; SKR6
UniProt ID: (Human) O00238, (Mouse) P36898
Entrez Gene ID: (Human) 658, (Mouse) 12167, (Rat) 310914
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transmembrane signaling receptor activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
kinase activity
transferase activity
BMP binding
SMAD binding
metal ion binding
BMP receptor activity
glycoprotein binding
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transferase activity, transferring phosphorus-containing groups
molecular_function
serine/threonine protein kinase receptor
cartilage condensation
ovarian cumulus expansion
osteoblast differentiation
eye development
chondrocyte differentiation
chondrocyte development
inflammatory response
transmembrane receptor protein serine/threonine kinase signaling pathway
dorsal/ventral pattern formation
positive regulation of gene expression
central nervous system neuron differentiation
cell differentiation
proteoglycan biosynthetic process
positive regulation of bone mineralization
BMP signaling pathway
retinal ganglion cell axon guidance
positive regulation of chondrocyte differentiation
ovulation cycle
camera-type eye development
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cartilage development
retina development in camera-type eye
bone development
endochondral bone morphogenesis
positive regulation of cartilage development
cellular response to growth factor stimulus
cellular response to BMP stimulus
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of chondrocyte proliferation
skeletal system development
protein phosphorylation
estrogen biosynthetic process
transforming growth factor beta receptor signaling pathway
phosphorylation
limb morphogenesis
positive regulation of cell differentiation
biological_process
signal transduction by protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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