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Proteintech
BPI Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
14368-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BPI Fusion Protein Ag5695 (238-587 aa encoded by BC040955)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IEGMSISAD LKLGSNPTSG KPTITCSSCS SHINSVHVHI SKSKVGWLIQ LFHKKIESAL RNKMNSQVCE KVTNSVSSKL QPYFQTLPVM TKIDSVAGIN YGLVAPPATT AETLDVQMKG EFYSENHHNP PPFAPPVMEF PAAHDRMVYL GLSDYFFNTA GLVYQEAGVL KMTLRDDMIP KESKFRLTTK FFGTFLPEVA KKFPNMKIQI HVSASTPPHL SVQPTGLTFY PAVDVQAFAV LPNSSLASLF LIGMHTTGSM EVSAESNRLV GELKLDRLLL ELKHSNIGPF PVELLQDIMN YIVPILVLPR VNEKLQKGFP LPTPARVQLY NVVLQPHQNF LLFGADVVYK (238-587 aa encoded by BC040955)
Target Information
The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. The binding of BPI to lipid A causes multiple anti-infective activities against gram-negative bacteria. These include: cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, neutralization of gram-negative bacterial LPS, opsonization of bacteria to enhance phagocytosis by neutrophils. BPI may be a critical determinant in the development of LPStriggered airways disease since airway epithelial cells constitutively express the BPI gene and produce the BPI protein. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antimicrobial protein; bactericidal permeability increasing protein (BPI) precursor; BPI; BPI fold containing family D, member 1; CAP 57; recombinant BPI holoprotein, rBPI; RP13-218F6_A.1; unnamed protein product
Gene Aliases: BPIFD1; rBPI
UniProt ID: (Human) P17213
Entrez Gene ID: (Human) 671
antibacterial humoral response
lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
negative regulation of macrophage activation
innate immune response
defense response to Gram-negative bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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