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BPTF/FALZ Polyclonal Antibody
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FIGURE: 1 / 4
BPTF/FALZ Antibody (BS-11641R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with BPTF/FALZ Polyclonal Antibody, Unconjugated (bs-11641R) at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB staining.
Product Details
BS-11641R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BPTF/FALZ, amino acids 2801-3046.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BPTF; bromodomain and PHD domain transcription factor; Bromodomain and PHD finger-containing transcription factor; bromodomain PHD finger transcription factor; Fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; Fetal Alzheimer antigen; nucleosome remodeling factor, large subunit; Nucleosome-remodeling factor subunit BPTF; unnamed protein product
Gene Aliases: 9430093H17Rik; BPTF; FAC1; FALZ; NEDDFL; NURF301
UniProt ID: (Human) Q12830
Entrez Gene ID: (Human) 2186, (Mouse) 207165, (Rat) 303617
negative regulation of transcription from RNA polymerase II promoter
embryonic placenta development
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
brain development
endoderm development
anterior/posterior pattern specification
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to nerve growth factor stimulus
transcription, DNA-templated
positive regulation of transcription, DNA-templated
response to wounding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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