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Active Motif
BRD7 Polyclonal Antibody
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Product Details
65724ACTMOTIF
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This BRD7 antibody was raised against a peptide within the C-terminal region of human BRD7.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Affinity chromatography
Storage buffer
70mM tris with 0.5mg/mL BSA, 0.07mM EDTA, 30% glycerol, 105mM NaCl, 31mM glycine
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 75 kDa bromodomain protein; Bromodomain-containing protein 7; Protein CELTIX-1; unnamed protein product
Gene Aliases: BP75; BRD7; CELTIX1; NAG4; SMARCI1
UniProt ID: (Human) Q9NPI1
Entrez Gene ID: (Human) 29117
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
regulation of mitotic cell cycle
Wnt signaling pathway
regulation of mitotic metaphase/anaphase transition
positive regulation of T cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of G0 to G1 transition
regulation of G1/S transition of mitotic cell cycle
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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