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Product Details
11962-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MCPH/BRIT1 Fusion Protein Ag2567 (253-610 aa encoded by BC030702)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: GSINDIKSD VCISSLVLKA NNIHSSPSFT HLDKSSPQKF LSNLSKEEIN LQRNIAGKVV TPHQKQAAGM SQETFEEKYR LSPTLSSTKG HLLIHSRPRS SSVKRKRVSH GSHSPPKEKC KRKRSTRRSI MPRLQLCRSE GRLQHVAGPA LEALSCGESS YDDYFSPDNL KERYSENLPP ESQLPSSPAQ LSCRSLSKKE RTSIFEMSDF SCVGKKTRTV DITNFTAKTI SSPRKTGNGE GRATSSCVTS APEEALRCCR QAGKEDACPE GNGFSYTIED PALPKGHDDD LTPLEGSLEE MKEAVGLKST QNKGTTSKIS NSSEGEAQSE HEPCFIVDCN METSTEEKEN LPGGYSGSM (253-610 aa encoded by BC030702)
Target Information
This protein is implicated in chromosome condensation and DNA damage induced cellular responses, and may play a role in neurogenesis and regulation of the size of the cerebral cortex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRCT-repeat inhibitor of TERT expression 1; BRIT 1; FLJ12847; Microcephalin; truncated microcephalin
Gene Aliases: 5430437K10Rik; BRIT1; D030046N04Rik; MCPH1; MCT
UniProt ID: (Human) Q8NEM0, (Mouse) Q7TT79
Entrez Gene ID: (Human) 79648, (Mouse) 244329
Molecular Function:
DNA metabolism protein
damaged DNA-binding protein
nucleic acid metabolism protein
cerebral cortex development
mitotic cell cycle arrest
establishment of mitotic spindle orientation
regulation of gene expression
regulation of kinase activity
regulation of centrosome cycle
regulation of inflammatory response
bone development
regulation of chromosome condensation
protein localization to centrosome
neuronal stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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