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14-3-3 Alpha/Beta/Gamma/Delta/Epsilon Polyclonal Antibody

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Product Details

BS-0237R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Yeast

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human 14-3-3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14-3-3 alpha; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3 protein epsilon; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma-subtype; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 tau; 14-3-3 theta; 14-3-3 zeta; 14-3-3E; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; HS1; KCIP-1; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; Mitochondrial import stimulation factor S1 subunit; MSF L; phospholipase A2; Prepronerve growth factor RNH-1; Protein 1054; Protein HS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein, theta; SEZ-2; signal transduction phosphoprotein; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; unnamed protein product; YWHAG

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Gene Aliases: 1110013I11Rik; 1300003C17Rik; 14-3-3; 14-3-3-zeta; 14-3-3E; 14-3-3G; 14-3-3GAMMA; 14-3-3t; 14-3-3z; 14-3-3zeta; 1C5; 2700028P07Rik; AA409740; AI596267; AL022924; AU019196; AU020854; AU021156; D7Bwg1348e; DEE56; EIEE56; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL2; HEL4; HS1; KCIP-1; MDCR; MDS; Msfs1; POPCHAS; PPP1R170; R74690; YWHAA; YWHAB; YWHAD; YWHAE; YWHAG; YWHAQ; YWHAZ

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UniProt ID: (Human) P31946, (Human) P62258, (Human) P61981, (Human) P27348, (Human) P63104, (Mouse) Q9CQV8, (Rat) P35213, (Rat) P62260, (Mouse) P62259, (Mouse) P61982, (Rat) P61983, (Rat) P68255, (Mouse) P68254, (Mouse) P63101, (Rat) P63102

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Entrez Gene ID: (Human) 7529, (Human) 7531, (Human) 7532, (Human) 10971, (Human) 7534, (Mouse) 54401, (Rat) 56011, (Rat) 29753, (Mouse) 22627, (Mouse) 22628, (Rat) 56010, (Rat) 25577, (Mouse) 22630, (Mouse) 22631, (Rat) 25578

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Function(s)
protein kinase inhibitor activity protein phosphatase inhibitor activity protein binding enzyme binding protein domain specific binding identical protein binding histone deacetylase binding macromolecular complex binding cadherin binding phosphoserine binding phosphoprotein binding protein sequestering activity RNA binding calcium channel regulator activity potassium channel regulator activity calcium channel inhibitor activity protein phosphatase binding MHC class II protein complex binding ubiquitin protein ligase binding signaling adaptor activity ion channel binding protein heterodimerization activity scaffold protein binding molecular function inhibitor activity protein kinase C binding insulin-like growth factor receptor binding protein kinase C inhibitor activity receptor tyrosine kinase binding phosphorylation-dependent protein binding 14-3-3 protein binding protein kinase binding DNA-binding transcription factor binding transcription corepressor activity protein C-terminus binding protein complex binding poly(A) RNA binding actin binding enzyme regulator activity protein N-terminus binding transcription factor binding scaffold/adaptor protein transporter
Process(es)
protein targeting signal transduction protein localization negative regulation of protein import into nucleus negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter MAPK cascade neuron migration cytoplasmic pattern recognition receptor signaling pathway regulation of heart rate by hormone ER to Golgi vesicle-mediated transport Golgi to plasma membrane transport regulation of mitotic cell cycle substantia nigra development hippocampus development cerebral cortex development cellular potassium ion homeostasis negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 4 signaling pathway protein localization to nucleus cellular response to heat hippo signaling positive regulation of hippo signaling intracellular signal transduction proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus regulation of cytosolic calcium ion concentration regulation of membrane repolarization protein localization to endoplasmic reticulum protein K11-linked ubiquitination membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of potassium ion transmembrane transport negative regulation of calcium ion export across plasma membrane cytoplasmic translation negative regulation of T cell mediated immune response to tumor cell positive regulation of T cell mediated immune response to tumor cell negative regulation of protein kinase activity regulation of signal transduction positive regulation of cell-cell adhesion SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels cellular response to insulin stimulus regulation of protein localization cellular response to amino acid starvation TORC1 signaling cellular response to glucose starvation regulation of neuron differentiation negative regulation of translational initiation positive regulation of translational initiation regulation of synaptic plasticity protein stabilization negative regulation of T cell activation positive regulation of T cell activation protein localization to lysosome protein K6-linked ubiquitination negative regulation of TORC1 signaling positive regulation of TORC1 signaling small GTPase mediated signal transduction negative regulation of ion transmembrane transport negative regulation of transcription from RNA polymerase II promoter angiogenesis respiratory system process protein phosphorylation lysosome organization synaptic target recognition lung development regulation of protein stability tube formation negative regulation of apoptotic process regulation of programmed cell death negative regulation of innate immune response establishment of Golgi localization ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade regulation of synapse maturation Golgi reassembly antibacterial innate immune response negative regulation of protein localization to nucleus regulation of lysosome organization negative regulation of protein dephosphorylation positive regulation of catalytic activity cytoplasmic sequestering of protein protein heterooligomerization negative regulation of protein serine/threonine kinase activity regulation of potassium ion transmembrane transporter activity negative regulation of peptidyl-serine dephosphorylation regulation of catalytic activity histamine secretion by mast cell protein targeting to mitochondrion regulation of cell death response to drug
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