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          • Primary Antibodies ›
          • GSK3B Antibodies

          Bioss

          GSK-3 Beta Monoclonal Antibody (4C6), FITC

          View all (85) GSK3B antibodies

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          Cite GSK-3 Beta Monoclonal Antibody (4C6), FITC

          Additional Information:
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          GSK-3 Beta Monoclonal Antibody (4C6), FITC

          Product Details

          BSM-33294M-FITC

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:300-5,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Mouse / IgG

          Class

          Monoclonal

          Type

          Antibody

          Clone

          4C6

          Immunogen

          KLH conjugated synthetic peptide derived from human GSK-3 Beta
          3D Epitope / Immunogen

          Conjugate

          FITC FITC FITC
          • Unconjugated
          • Biotin 
          • Cyanine3
          • Cyanine5 
          • Cyanine5.5 
          • Cyanine7
          • HRP
          • Request custom conjugation

          Excitation/Emission Max

          498/517 nm View spectra spectra

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein G

          Storage buffer

          TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.03% ProClin 300

          Storage conditions

          -20°C, store in dark

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: EC 2.7.11.26; FA; factor A; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3B; kinase; mGSK3beta; pp37; serine/threonine-protein kinase GSK3B; unnamed protein product

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          Gene Aliases: 7330414F15Rik; 8430431H08Rik; GSK-3; GSK-3beta; GSK3

          View more View less

          UniProt ID: (Human) P49841, (Mouse) Q9WV60, (Rat) P18266

          View more View less

          Entrez Gene ID: (Human) 2932, (Mouse) 56637, (Rat) 84027

          View more View less

          Function(s)
          protease binding p53 binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding beta-catenin binding kinase activity protein kinase binding ubiquitin protein ligase binding protein kinase A catalytic subunit binding dynactin binding tau protein binding tau-protein kinase activity NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding dynein complex binding scaffold protein binding protein serine kinase activity integrin binding ionotropic glutamate receptor binding protein serine/threonine kinase binding
          Process(es)
          epithelial to mesenchymal transition positive regulation of cell-matrix adhesion heart valve development glycogen metabolic process protein phosphorylation ER overload response mitochondrion organization meiosis I circadian rhythm insulin receptor signaling pathway negative regulation of signal transduction positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression negative regulation of epithelial to mesenchymal transition positive regulation of protein processing regulation of neuron projection development Wnt signaling pathway peptidyl-serine phosphorylation viral protein processing hippocampus development establishment of cell polarity maintenance of cell polarity cell differentiation negative regulation of cell migration regulation of axon extension neuron projection development negative regulation of protein complex assembly positive regulation of protein complex assembly positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway negative regulation of TOR signaling positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of type I interferon production regulation of protein localization regulation of microtubule-based process response to endoplasmic reticulum stress intracellular signal transduction cellular response to interleukin-3 regulation of circadian rhythm regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process protein kinase B signaling positive regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of glycogen biosynthetic process positive regulation of cilium assembly positive regulation of protein catabolic process negative regulation of smoothened signaling pathway protein autophosphorylation regulation of protein export from nucleus positive regulation of protein export from nucleus regulation of dendrite morphogenesis regulation of axonogenesis canonical Wnt signaling pathway excitatory postsynaptic potential intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of microtubule cytoskeleton organization negative regulation of calcineurin-NFAT signaling cascade superior temporal gyrus development cellular response to retinoic acid cellular response to glucocorticoid stimulus negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand presynaptic modulation of chemical synaptic transmission neuron projection organization regulation of microtubule anchoring at centrosome beta-arrestin-dependent dopamine receptor signaling pathway positive regulation of substrate adhesion-dependent cell spreading regulation of cellular response to heat negative regulation of protein localization to nucleus regulation of long-term synaptic potentiation positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to cilium negative regulation of TORC2 signaling negative regulation of dopaminergic neuron differentiation cellular response to beta-amyloid negative regulation of protein localization to centrosome positive regulation of protein localization to centrosome positive regulation of establishment of protein localization negative regulation of type B pancreatic cell development negative regulation of glycogen (starch) synthase activity positive regulation of cardiac muscle cell differentiation negative regulation of mesenchymal stem cell differentiation G1/S transition of mitotic cell cycle re-entry into mitotic cell cycle regulation of cell growth cytoplasmic translational initiation protein export from nucleus cytoskeleton organization establishment or maintenance of cell polarity regulation of mitotic cell cycle axonogenesis myoblast fusion organ morphogenesis response to zinc ion negative regulation of cardiac muscle hypertrophy positive regulation of peptidyl-threonine phosphorylation positive regulation of mitochondrial membrane potential negative regulation of neuron projection development negative regulation of neuron maturation myotube differentiation phosphorylation cell migration positive regulation of cell migration SCF-dependent proteasomal ubiquitin-dependent protein catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of osteoblast proliferation negative regulation of smooth muscle cell apoptotic process protein localization to microtubule cellular response to hepatocyte growth factor stimulus hepatic stellate cell activation TORC2 signaling positive regulation of apoptotic process negative regulation of MAP kinase activity fat cell differentiation regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of translation positive regulation of axon extension negative regulation of synaptic growth at neuromuscular junction positive regulation of synaptic growth at neuromuscular junction positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin receptor signaling pathway bone remodeling regulation of neuronal synaptic plasticity positive regulation of smooth muscle cell proliferation negative regulation of dendrite morphogenesis negative regulation of nitric-oxide synthase activity negative regulation of developmental process regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cell growth involved in cardiac muscle cell development cellular response to mechanical stimulus positive regulation of osteoclast proliferation hepatocyte apoptotic process regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of modification of postsynaptic structure autosome genomic imprinting response to methamphetamine hydrochloride conditioned place preference negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of dendrite development positive regulation of excitatory postsynaptic potential positive regulation of DNA biosynthetic process positive regulation of stem cell differentiation negative regulation of neuron migration response to xenobiotic stimulus response to activity response to estradiol response to insulin cellular response to erythropoietin cellular response to hydrogen peroxide cellular response to iron(II) ion cellular response to lithium ion response to epinephrine response to L-glutamate cellular response to dopamine response to insulin-like growth factor stimulus response to ultrasound response to angiotensin
          It has to be done as per old AB suggested Products section.

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