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OriGene
Beta 2 Adaptin Polyclonal Antibody
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Product Details
TA590760
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the Middle Region of the target protein.
Conjugate
Form
Liquid
Concentration
0.86423 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptin, beta 2 (beta); Adaptor protein complex AP-2 subunit beta; adaptor related protein complex 2 beta 1 subunit; Adaptor-related protein complex 2 subunit beta; AP-2 complex subunit beta; AP105B; beta adaptin; Beta-2-adaptin; Beta-adaptin; beta2-adaptin; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor; clathrin-associated/assembly/adaptor protein, large, beta 1; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; testicular tissue protein Li 22; unnamed protein product
Gene Aliases: ADTB2; AP105B; AP2-BETA; AP2B1; CLAPB1
UniProt ID: (Human) P63010
Entrez Gene ID: (Human) 163
kidney development
cardiac septum development
ventricular septum development
intracellular protein transport
endocytosis
chemical synaptic transmission
neurotransmitter secretion
heart development
protein transport
vesicle-mediated transport
aorta development
positive regulation of endocytosis
clathrin coat assembly
synaptic vesicle endocytosis
coronary vasculature development
clathrin-mediated endocytosis
postsynaptic neurotransmitter receptor internalization
positive regulation of protein localization to membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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