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Invitrogen

C-Peptide Polyclonal Antibody

1 Reference
View all (9) C-Peptide antibodies

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Product Details

PA5-85595

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

ELISA (ELISA)

1:1,000-1:10,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human C-Peptide. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.36 mg/mL

Amount

136 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792735

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Chimpanzee (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cpeptide; INSU1; INSU2; INSU3B; INSUA; INSUB; INSUC; Insulin; insulin splice variant; insulin variant; INS-splice; Insulin-1; preproinsulin; proinsulin

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Gene Aliases: IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins1; Ins2-rs1; IRDN; MODY10; PNDM4

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UniProt ID: (Human) P01308, (Rat) P01322, (Mouse) P01325

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Entrez Gene ID: (Human) 3630, (Rat) 24505, (Mouse) 16333

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Function(s)
protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity protein binding identical protein binding receptor agonist activity chaperone binding growth factor
Process(es)
positive regulation of cytokine production negative regulation of acute inflammatory response glucose metabolic process regulation of transcription, DNA-templated acute-phase response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of cell proliferation insulin receptor signaling pathway positive regulation of gene expression negative regulation of gene expression positive regulation of nitric oxide mediated signal transduction positive regulation of neuron projection development positive regulation of cell growth positive regulation of cell migration regulation of protein localization nitric oxide-cGMP-mediated signaling pathway TORC1 signaling wound healing negative regulation of protein catabolic process vasodilation glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of cell differentiation negative regulation of gluconeogenesis positive regulation of glycogen biosynthetic process positive regulation of translation negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation positive regulation of lipid biosynthetic process regulation of synaptic plasticity regulation of protein secretion negative regulation of protein secretion positive regulation of protein secretion cognition negative regulation of lipid catabolic process positive regulation of nitric-oxide synthase activity positive regulation of protein kinase B signaling fatty acid homeostasis negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst positive regulation of peptide hormone secretion positive regulation of brown fat cell differentiation positive regulation of protein localization to nucleus positive regulation of long-term synaptic potentiation cellular response to oxygen-containing compound negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of feeding behavior MAPK cascade regulation of cellular amino acid metabolic process response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling glucose transport regulation of transmembrane transporter activity activation of protein kinase B activity positive regulation of cellular protein metabolic process negative regulation of protein oligomerization negative regulation of NAD(P)H oxidase activity response to cytokine response to peptide hormone positive regulation of DNA replication negative regulation of proteolysis positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity response to cAMP carbohydrate metabolic process
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