Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: GIPGEPGEEG RYKQKFQSVF TVTRQTHQPP APNSLIRFNA VLTNPQGDYD TSTGKFTCKV PGLYYFVYHA SHTANLCVLL YRSGVKVVTF CGHTSKTNQV NSGGVLLRLQ VGEEVWLAVN DYYDMVGIQG SD
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 73%.
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Complement C1q subcomponent subunit C; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide
Gene Aliases: C1Q-C; C1QC; C1QG
UniProt ID: (Human) P02747
Entrez Gene ID: (Human) 714
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