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Bioss

C5b-9 Polyclonal Antibody

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Product Details

BS-2673R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified Human SC5b-9 Complex.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; C5b-9; C9 complement protein; Complement C5; complement component 5; complement component 6; complement component 7; complement component 9; Complement component C6; complement component C6 precursor peptide; Complement component C7; Complement component C9; complement protein C7 precursor; MAC Complex; Membrane Attack Complex; prepro-C5; unnamed protein product

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Gene Aliases: A530026G17; ARMD15; AW111623; C5; C5a; C5b; C5D; C6; C7; C9; C9D; CPAMD4; ECLZB; Gm1238; Hc; RGD1561905

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UniProt ID: (Human) P01031, (Mouse) E9Q6D8, (Rat) Q811M5, (Human) P13671, (Human) P10643, (Mouse) D3YXF5, (Human) P02748, (Mouse) P06683, (Rat) Q62930

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Entrez Gene ID: (Rat) 362119, (Human) 727, (Mouse) 12274, (Rat) 24237, (Human) 729, (Rat) 117517, (Human) 730, (Mouse) 109828, (Human) 735, (Mouse) 12279, (Rat) 117512

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Function(s)
C5a anaphylatoxin chemotactic receptor binding G-protein coupled receptor binding endopeptidase inhibitor activity receptor binding protein binding chemokine activity receptor agonist activity molecular_function protease inhibitor
Process(es)
in utero embryonic development leukocyte migration involved in inflammatory response cellular calcium ion homeostasis chemotaxis inflammatory response complement activation, alternative pathway complement activation, classical pathway positive regulation of vascular endothelial growth factor production negative regulation of norepinephrine secretion negative regulation of macrophage chemotaxis negative regulation of dopamine secretion glucose homeostasis positive regulation of angiogenesis positive regulation of chemotaxis positive regulation of chemokine secretion complement activation, lectin pathway immune system process regulation of immune system process complement activation signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell migration leukocyte chemotaxis killing of cells of other organism positive regulation of chemokine production innate immune response regulation of chemotaxis cell chemotaxis complement activation, GZMK pathway positive regulation of activation of membrane attack complex positive regulation of apoptotic process positive regulation of complement activation immune response cytolysis positive regulation of immune response cellular sodium ion homeostasis cell killing protein homooligomerization blood coagulation
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