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Bioss
C5b-9 Polyclonal Antibody
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FIGURE: 1 / 2
C5b-9 Antibody (BS-2673R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with C5b-9 Polyclonal Antibody, Unconjugated (bs-2673R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB ... View More
Product Details
BS-2673R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified Human SC5b-9 Complex.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; C5b-9; Complement C5; Complement component C6; Complement component C7; Complement component C9; MAC Complex; Membrane Attack Complex; prepro-C5
Gene Aliases: A530026G17; ARMD15; AW111623; C5; C5a; C5b; C5D; C6; C7; C9; C9D; CPAMD4; ECLZB; Gm1238; Hc; RGD1561905
UniProt ID: (Human) P01031, (Human) P13671, (Rat) Q811M5, (Human) P10643, (Human) P02748, (Mouse) P06683, (Rat) Q62930
Entrez Gene ID: (Human) 727, (Rat) 362119, (Human) 729, (Mouse) 12274, (Rat) 24237, (Rat) 117517, (Human) 730, (Mouse) 109828, (Human) 735, (Mouse) 12279, (Rat) 117512
activation of MAPK activity
in utero embryonic development
chemotaxis
response to stress
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor production
negative regulation of macrophage chemotaxis
negative regulation of endopeptidase activity
cytolysis
regulation of complement activation
positive regulation of angiogenesis
cell chemotaxis
positive regulation of chemokine secretion
mitophagy in response to mitochondrial depolarization
leukocyte migration involved in inflammatory response
cellular calcium ion homeostasis
negative regulation of norepinephrine secretion
negative regulation of dopamine secretion
glucose homeostasis
positive regulation of chemotaxis
positive regulation of activation of membrane attack complex
innate immune response
positive regulation of apoptotic process
positive regulation of complement activation
immune response
cellular sodium ion homeostasis
immune system process
blood coagulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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