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Proteintech
C8orf4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
26279-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C8orf4 Fusion Protein Ag23930 (1-106 aa encoded by BC021672)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKAKRSHQA IIMSTSLRVS PSIHGYHFDT ASRKKAVGNI FENTDQESLE RLFRNSGDKK AEERAKIIFA IDQDVEEKTR ALMALKKRTK DKLFQFLKLR KYSIKVH (1-106 aa encoded by BC021672)
Target Information
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human thyroid cancer 1; protein C8orf4; protein C8orf4 homolog; thyroid cancer protein 1; thyroid cancer-1; unnamed protein product
Gene Aliases: 1110065B09Rik; 1810011O10Rik; C8orf4; TC-1; TC1
UniProt ID: (Human) Q9NR00, (Mouse) Q9D915
Entrez Gene ID: (Human) 56892, (Mouse) 69068
endothelial cell activation involved in immune response
regulation of transcription, DNA-templated
cellular response to heat
negative regulation of Notch signaling pathway
positive regulation of NIK/NF-kappaB signaling
regulation of cell cycle G1/S phase transition
negative regulation of apoptotic process
regulation of hemopoiesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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