This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
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Protein Aliases: human thyroid cancer 1; TC-1; Thyroid cancer protein 1; thyroid cancer-1; Transcriptional and immune response regulator; uncharacterized protein C8orf4 homolog
Gene Aliases: 1110065B09Rik; AW121743; AW321058; C8orf4; TC-1; TC1; TCIM