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Invitrogen
CALM Polyclonal Antibody
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Product Details
PA5-31344
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CALM. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A549.
Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly protein; unnamed protein product
Gene Aliases: CALM; CLTH; LAP; PICALM
UniProt ID: (Human) Q13492
Entrez Gene ID: (Human) 8301
SNARE binding
beta-amyloid binding
protein binding
phospholipid binding
1-phosphatidylinositol binding
phosphatidylinositol-4,5-bisphosphate binding
clathrin binding
small GTPase binding
clathrin heavy chain binding
cadherin binding
tau protein binding
low-density lipoprotein particle receptor binding
cellular iron ion homeostasis
endocytosis
receptor-mediated endocytosis
membrane budding
axonogenesis
learning or memory
negative regulation of gene expression
synaptic vesicle maturation
vesicle-mediated transport
endosomal transport
hemopoiesis
regulation of endocytosis
receptor internalization
regulation of protein localization
cargo loading into vesicle
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
regulation of receptor-mediated endocytosis
negative regulation of receptor-mediated endocytosis
clathrin coat assembly
dendrite morphogenesis
multicellular organismal iron ion homeostasis
protein-containing complex assembly
clathrin-mediated endocytosis
regulation of vesicle size
membrane bending
amyloid-beta clearance by transcytosis
regulation of beta-amyloid formation
positive regulation of beta-amyloid formation
regulation of amyloid precursor protein catabolic process
positive regulation of amyloid precursor protein catabolic process
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell surface
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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