Peptide sequence: AALLTIPEAE KSPLMSEFQS QISSNPELAA IFESIQKDSS STNLESMDTS
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cullin-associated and neddylation-dissociated 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZp434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; p120 CAND1; TBP interacting protein; TBP-interacting protein; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A
Gene Aliases: 2310038O07Rik; 6330512O03Rik; AI195005; AI846556; CAND1; D10Ertd516e; KIAA0829; mKIAA0829; TIP120; TIP120A; Tp120a
Molecular Function: ubiquitin-protein ligase