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Bioss
CAP Polyclonal Antibody
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Product Details
BS-9759R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Brd4/CAP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRD4-NUT FUSION; bromodomain-containing 5; Bromodomain-containing protein 4; chromosome-associated protein; female sterile homeotic related gene 4; fsh-like protein; HUNKI; MCAP; Mitotic chromosome-associated protein; Protein HUNK1
Gene Aliases: BRD4; Brd5; CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP; WI-11513
UniProt ID: (Human) O60885, (Mouse) Q9ESU6
Entrez Gene ID: (Human) 23476, (Rat) 362844, (Mouse) 57261
transcription regulatory region sequence-specific DNA binding
p53 binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
protein serine/threonine kinase activity
protein binding
RNA polymerase II carboxy-terminal domain kinase activity
enzyme binding
protein binding, bridging
histone binding
RNA polymerase II C-terminal domain binding
P-TEFb complex binding
histone H4 reader activity
histone H4K12ac reader activity
histone H4K5ac reader activity
histone H4K16ac reader activity
histone H4K8ac reader activity
histone H3K9ac reader activity
histone H3K27ac reader activity
DNA binding
lysine-acetylated histone binding
regulation of transcription involved in G1/S transition of mitotic cell cycle
inner cell mass cell proliferation
chromatin remodeling
protein phosphorylation
cellular response to DNA damage stimulus
chromosome segregation
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA binding
histone H4-K12 acetylation
histone H3-K14 acetylation
positive regulation of transcription from RNA polymerase II promoter
regulation of inflammatory response
regulation of phosphorylation of RNA polymerase II C-terminal domain
negative regulation of DNA damage checkpoint
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
chromatin organization
regulation of transcription from RNA polymerase II promoter
negative regulation by host of viral transcription
positive regulation of transcription, DNA-templated
positive regulation of T-helper 17 cell lineage commitment
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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