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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CARD12|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27686 targets CARD12 in WB applications and shows reactivity with Human samples.
The PA5-27686 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CARD12.
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
and NACHT-containing protein; CARD; CARD, LRR, and NACHT-containing protein; CARD12; caspase recruitment domain family; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; ice protease-activating f; ICE-protease activating factor; IPAF; LRR; member 12; NLR family, CARD domain containing 4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF; NLRC4; UNQ6189/PRO20215