|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CARD12|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27686 targets CARD12 in WB applications and shows reactivity with Human samples.
The PA5-27686 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CARD12.
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: and NACHT-containing protein; CARD; CARD, LRR, and NACHT-containing protein; CARD12; caspase recruitment domain family; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CLAN; Clan protein; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; ice protease-activating f; Ice protease-activating factor; ICE-protease activating factor; IPAF; LRR; member 12; NLR family CARD domain-containing protein 4; NLR family, CARD domain containing 4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Gene Aliases: AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF; NLRC4; UNQ6189/PRO20215
UniProt ID: (Human) Q9NPP4
Entrez Gene ID: (Human) 58484
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