Proteintech

CARD9 Polyclonal Antibody

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CARD9 Antibody in Western Blot (WB) — Human placenta tissue were subjected to SDS PAGE followed by western blot with 10669-1-AP (CARD9 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

10669-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:3,000	View 5 publications 5 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CARD9 Fusion Protein Ag1057 (193-492 aa encoded by BC008877) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: SEEKGAALM RNRDLQLEID QLKHSLMKAE DDCKVERKHT LKLRHAMEQR PSQELLWELQ QEKALLQARV QELEASVQEG KLDRSSPYIQ VLEEDWRQAL RDHQEQANTI FSLRKDLRQG EARRLRCMEE KEMFELQCLA LRKDSKMYKD RIEAILLQME EVAIERDQAI ATREELHAQH ARGLQEKDAL RKQVRELGEK ADELQLQVFQ CEAQLLAVEG RLRRQQLETL VLSSDLEDGS PRRSQELSLP QDLEDTQLSD KGCLAGGGSP KQPFAALHQE QVLRNPHDAG PAGLPGIGAV C (193-492 aa encoded by BC008877)

Target Information

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Early-Onset Invasive Infection Due to Corynespora cassiicola Associated with Compound Heterozygous CARD9 Mutations in a Colombian Patient.

Journal of clinical immunology

Arango-Franco CA,Moncada-Vélez M,Beltrán CP,Berrío I,Mogollón C,Restrepo A,Trujillo M,Osorio SD,Castro L,Gómez LV,Muñoz AM,Molina V,Del Río Cobaleda DY,Ruiz AC,Garcés C,Alzate JF,Cabarcas F,Orrego JC,Casanova JL,Bustamante J,Puel A,Arias AA,Franco JL

Mon Oct 01 00:00:00 EDT 2018

Extrapulmonary Aspergillus infection in patients with CARD9 deficiency.

JCI insight

Rieber N,Gazendam RP,Freeman AF,Hsu AP,Collar AL,Sugui JA,Drummond RA,Rongkavilit C,Hoffman K,Henderson C,Clark L,Mezger M,Swamydas M,Engeholm M,Schüle R,Neumayer B,Ebel F,Mikelis CM,Pittaluga S,Prasad VK,Singh A,Milner JD,Williams KW,Lim JK,Kwon-Chung KJ,Holland SM,Hartl D,Kuijpers TW,Lionakis MS

Thu Oct 20 00:00:00 EDT 2016

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.

PLoS pathogens

Drummond RA,Collar AL,Swamydas M,Rodriguez CA,Lim JK,Mendez LM,Fink DL,Hsu AP,Zhai B,Karauzum H,Mikelis CM,Rose SR,Ferre EM,Yockey L,Lemberg K,Kuehn HS,Rosenzweig SD,Lin X,Chittiboina P,Datta SK,Belhorn TH,Weimer ET,Hernandez ML,Hohl TM,Kuhns DB,Lionakis MS

Tue Dec 01 00:00:00 EST 2015

Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X).

The Pediatric infectious disease journal

Herbst M,Gazendam R,Reimnitz D,Sawalle-Belohradsky J,Groll A,Schlegel PG,Belohradsky B,Renner E,Klepper J,Grimbacher B,Kuijpers T,Liese J

Tue Sep 01 00:00:00 EDT 2015

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.

Blood

Drewniak A,Gazendam RP,Tool AT,van Houdt M,Jansen MH,van Hamme JL,van Leeuwen EM,Roos D,Scalais E,de Beaufort C,Janssen H,van den Berg TK,Kuijpers TW

Thu Mar 28 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: card 9; caspase recruitment domain family, member 9; caspase recruitment domain protein 9; Caspase recruitment domain-containing protein 9; hCARD9; rCARD9; RP11-413M3.9

Gene Aliases: CANDF2; CARD9; Gm782; hCARD9

UniProt ID: (Human) Q9H257, (Rat) Q9EPY0, (Mouse) A2AIV8

Entrez Gene ID: (Human) 64170, (Rat) 64171, (Mouse) 332579

Function(s)

stimulatory C-type lectin receptor signaling pathway I-kappaB kinase/NF-kappaB signaling response to fungus response to peptidoglycan response to muramyl dipeptide positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade response to drug regulation of tumor necrosis factor biosynthetic process regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA regulation of interleukin-2 biosynthetic process innate immune response regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade defense response to Gram-positive bacterium defense response to virus positive regulation of innate immune response positive regulation of NF-kappaB transcription factor activity immune system process

Process(es)

protein binding protein homodimerization activity CARD domain binding protein domain specific binding

CARD9 Polyclonal Antibody

Product Details

10669-1-AP

Western Blot (WB)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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