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Proteintech
CASK Polyclonal Antibody
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Product Details
55277-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize all the isoform of CASK.
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK protein; CASK; hCASK; membrane associated guanylate kinase; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; RP23-278L4.1; trinucleotide repeat containing 8
Gene Aliases: CAGH39; CAMGUK; CASK; CMG; DXPri1; DXRib1; FGS4; hCASK; LIN-2; LIN2; MICPCH; mLin-2; MRXSNA; Pals3; TNRC8
UniProt ID: (Human) O14936, (Rat) Q62915, (Mouse) O70589
Entrez Gene ID: (Human) 8573, (Rat) 29647, (Mouse) 12361
nucleotide binding
guanylate kinase activity
protein kinase activity
protein serine/threonine kinase activity
receptor binding
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
neurexin family protein binding
protein serine kinase activity
transcription coactivator activity
calmodulin-dependent protein kinase activity
G-protein coupled receptor activity
protein C-terminus binding
PDZ domain binding
protein complex binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
scaffold/adaptor protein
negative regulation of cell-matrix adhesion
cell adhesion
protein localization
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
GMP metabolic process
GDP metabolic process
regulation of neurotransmitter secretion
establishment of localization in cell
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of synaptic vesicle exocytosis
protein complex assembly
protein phosphorylation
intracellular protein transport
G-protein coupled receptor signaling pathway
regulation of nucleic acid-templated transcription
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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