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Bioss
CATSPER3 Polyclonal Antibody
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Product Details
BS-7136R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CATSPER3, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca(v)-like protein; calcium channel repeat containing 1; Cation channel sperm-associated protein 3; CatSper3; One-repeat calcium channel-like protein; putative ion channel CatSper3; unnamed protein product
Gene Aliases: 4921522D01Rik; CACRC; CATSPER3
UniProt ID: (Human) Q86XQ3, (Mouse) Q80W99
Entrez Gene ID: (Human) 347732, (Rat) 290989, (Mouse) 76856
ion transport
sodium ion transport
calcium ion transport
spermatogenesis
cell differentiation
sperm motility
ion transmembrane transport
sperm capacitation
establishment of localization in cell
transmembrane transport
calcium ion transmembrane transport
regulation of ion transmembrane transport
calcium ion import
membrane depolarization during action potential
transport
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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