Proteintech

CCDC22 Polyclonal Antibody

FIGURE: 1 / 4

CCDC22 Antibody (16636-1-AP) in WB

Mouse colon tissue were subjected to SDS PAGE followed by western blot with 16636-1-AP (CCDC22 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

CCDC22 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16636-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCDC22 Fusion Protein Ag9980 (283-628 aa encoded by BC000972)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AKTGAPKGS RFTHSEKFTF HLEPQAQATQ VSDVPATSRR PEQVTWAAQE QELESLREQL EGVNRSIEEV EADMKTLGVS FVQAESECRH SKLSTAEREQ ALRLKSRAVE LLPDGTANLA KLQLVVENSA QRVIHLAGQW EKHRVPLLAE YRHLRKLQDC RELESSRRLA EIQELHQSVR AAAEEARRKE EVYKQLMSEL ETLPRDVSRL AYTQRILEIV GNIRKQKEEI TKILSDTKEL QKEINSLSGK LDRTFAVTDE LVFKDAKKDD AVRKAYKYLA ALHENCSQLI QTIEDTGTIM REVRDLEEQI ETELGKKTLS NLEKIREDYR ALRQENAGLL GRVREA (283-628 aa encoded by BC000972)

Target Information

CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.

Science immunology

Shirai T,Nakai A,Ando E,Fujimoto J,Leach S,Arimori T,Higo D,van Eerden FJ,Tulyeu J,Liu YC,Okuzaki D,Murayama MA,Miyata H,Nunomura K,Lin B,Tani A,Kumanogoh A,Ikawa M,Wing JB,Standley DM,Takagi J,Suzuki K

Fri Mar 31 00:00:00 UTC 2023

COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.

Molecular cancer research : MCR

Wang S,Liu Y,Li S,Chen Y,Liu Y,Yan J,Wu J,Li J,Wang L,Xiang R,Shi Y,Qin X,Yang S

Wed Mar 01 00:00:00 UTC 2023

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.

Cell

Healy MD,McNally KE,Butkovič R,Chilton M,Kato K,Sacharz J,McConville C,Moody ERR,Shaw S,Planelles-Herrero VJ,Yadav SKN,Ross J,Borucu U,Palmer CS,Chen KE,Croll TI,Hall RJ,Caruana NJ,Ghai R,Nguyen THD,Heesom KJ,Saitoh S,Berger I,Schaffitzel C,Williams TA,Stroud DA,Derivery E,Collins BM,Cullen PJ

Thu May 11 00:00:00 UTC 2023

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins.

Structure (London, England : 1993)

Healy MD,Sacharz J,McNally KE,McConville C,Tillu VA,Hall RJ,Chilton M,Cullen PJ,Mobli M,Ghai R,Stroud DA,Collins BM

Thu Dec 01 00:00:00 UTC 2022

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.

Molecular biology reports

Hong Y,Sun H,Hong X,Yang CP,Billadeau DD,Wang T,Deng ZH

Thu Sep 01 00:00:00 UTC 2022

WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress.

Molecular biology reports

Hong Y,Sun H,Hong X,Yang CP,Billadeau DD,Wang T,Deng ZH

Thu Sep 01 00:00:00 UTC 2022

Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion.

Molecular metabolism

Yang L,Fye MA,Yang B,Tang Z,Zhang Y,Haigh S,Covington BA,Bracey K,Taraska JW,Kaverina I,Qu S,Chen W

Thu Sep 01 00:00:00 UTC 2022

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

Cell

Daniloski Z,Jordan TX,Wessels HH,Hoagland DA,Kasela S,Legut M,Maniatis S,Mimitou EP,Lu L,Geller E,Danziger O,Rosenberg BR,Phatnani H,Smibert P,Lappalainen T,tenOever BR,Sanjana NE

Thu Jan 07 00:00:00 UTC 2021

Regulation of murine copper homeostasis by members of the COMMD protein family.

Disease models & mechanisms

Singla A,Chen Q,Suzuki K,Song J,Fedoseienko A,Wijers M,Lopez A,Billadeau DD,van de Sluis B,Burstein E

Fri Jan 01 00:00:00 UTC 2021

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.

Nature communications

Zhu Y,Feng F,Hu G,Wang Y,Yu Y,Zhu Y,Xu W,Cai X,Sun Z,Han W,Ye R,Qu D,Ding Q,Huang X,Chen H,Xu W,Xie Y,Cai Q,Yuan Z,Zhang R

Thu Feb 11 00:00:00 UTC 2021

Retromer is involved in epithelial Na⁺ channel trafficking.

American journal of physiology. Renal physiology

Cheung TT,Geda AC,Ware AW,Rasulov SR,Tenci P,Hamilton KL,McDonald FJ

Sun Nov 01 00:00:00 UTC 2020

COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages.

iScience

Ben Shlomo S,Mouhadeb O,Cohen K,Varol C,Gluck N

Fri Apr 26 00:00:00 UTC 2019

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

Journal of molecular biology

Hunter MR,Hesketh GG,Benedyk TH,Gingras AC,Graham SC

Fri Jul 06 00:00:00 UTC 2018

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

Journal of molecular biology

Hunter MR,Hesketh GG,Benedyk TH,Gingras AC,Graham SC

Fri Jul 06 00:00:00 UTC 2018

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

Nature cell biology

McNally KE,Faulkner R,Steinberg F,Gallon M,Ghai R,Pim D,Langton P,Pearson N,Danson CM,Nägele H,Morris LL,Singla A,Overlee BL,Heesom KJ,Sessions R,Banks L,Collins BM,Berger I,Billadeau DD,Burstein E,Cullen PJ

Sun Oct 01 00:00:00 UTC 2017

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

Nature cell biology

Sun Oct 01 00:00:00 UTC 2017

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

Nature communications

Bartuzi P,Billadeau DD,Favier R,Rong S,Dekker D,Fedoseienko A,Fieten H,Wijers M,Levels JH,Huijkman N,Kloosterhuis N,van der Molen H,Brufau G,Groen AK,Elliott AM,Kuivenhoven JA,Plecko B,Grangl G,McGaughran J,Horton JD,Burstein E,Hofker MH,van de Sluis B

Fri Mar 11 00:00:00 UTC 2016

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

Nature communications

Fri Mar 11 00:00:00 UTC 2016

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

The Journal of cell biology

Li H,Koo Y,Mao X,Sifuentes-Dominguez L,Morris LL,Jia D,Miyata N,Faulkner RA,van Deursen JM,Vooijs M,Billadeau DD,van de Sluis B,Cleaver O,Burstein E

Mon Nov 09 00:00:00 UTC 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

The Journal of cell biology

Li H,Koo Y,Mao X,Sifuentes-Dominguez L,Morris LL,Jia D,Miyata N,Faulkner RA,van Deursen JM,Vooijs M,Billadeau DD,van de Sluis B,Cleaver O,Burstein E

Mon Nov 09 00:00:00 UTC 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

The Journal of cell biology

Li H,Koo Y,Mao X,Sifuentes-Dominguez L,Morris LL,Jia D,Miyata N,Faulkner RA,van Deursen JM,Vooijs M,Billadeau DD,van de Sluis B,Cleaver O,Burstein E

Mon Nov 09 00:00:00 UTC 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

The Journal of cell biology

Li H,Koo Y,Mao X,Sifuentes-Dominguez L,Morris LL,Jia D,Miyata N,Faulkner RA,van Deursen JM,Vooijs M,Billadeau DD,van de Sluis B,Cleaver O,Burstein E

Mon Nov 09 00:00:00 UTC 2015

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Molecular biology of the cell

Phillips-Krawczak CA,Singla A,Starokadomskyy P,Deng Z,Osborne DG,Li H,Dick CJ,Gomez TS,Koenecke M,Zhang JS,Dai H,Sifuentes-Dominguez LF,Geng LN,Kaufmann SH,Hein MY,Wallis M,McGaughran J,Gecz J,Sluis Bv,Billadeau DD,Burstein E

Thu Jan 01 00:00:00 UTC 2015

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Molecular biology of the cell

Thu Jan 01 00:00:00 UTC 2015

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Molecular biology of the cell

Thu Jan 01 00:00:00 UTC 2015

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Molecular biology of the cell

Thu Jan 01 00:00:00 UTC 2015

SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells.

Molecular bioSystems

Qi D,Wang Q,Li H,Zhang T,Lan R,Kwong DW,Wong WK,Wong KL,Li S,Lu F

Sun Nov 01 00:00:00 UTC 2015

SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells.

Molecular bioSystems

Qi D,Wang Q,Li H,Zhang T,Lan R,Kwong DW,Wong WK,Wong KL,Li S,Lu F

Sun Nov 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: ccdc22 {ECO:0000250|UniProtKB:O60826}; Coiled-coil domain-containing protein 22; coiled-coil domain-containing protein 22 {ECO:0000250|UniProtKB:O60826}

View more View less

Gene Aliases: AI481216; CCDC22; CXorf37; DXImx40e; JM1; Ppp1r3f; RGD1560910; RTSC2; Sfc22

View more View less

UniProt ID: (Human) O60826, (Mouse) Q9JIG7, (Rat) P86182

View more View less

Entrez Gene ID: (Human) 28952, (Mouse) 54638, (Rat) 317381

View more View less

Function(s)

protein binding cullin family protein binding

Process(es)

cellular copper ion homeostasis Golgi to plasma membrane transport cytoplasmic sequestering of NF-kappaB protein transport positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

CCDC22 Polyclonal Antibody

CCDC22 Antibody (16636-1-AP) in WB

Product Details

16636-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!