|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 298 and 360 of Human CCNDBP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28456 targets CCNDBP1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28456 immunogen is synthetic peptide corresponding to a region within amino acids 298 and 360 of Human CCNDBP1.
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cyclin D-type binding-protein 1; Cyclin-D1-binding protein 1; D-type cyclin-interacting protein 1; DIP1; GCIP; grap2 and cyclin D interacting protein; Grap2 and cyclin-D-interacting protein; HHM; Human homolog of Maid
Gene Aliases: CCNDBP1; DIP1; GCIP; HHM
UniProt ID: (Human) O95273
Entrez Gene ID: (Human) 23582
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