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Fabgennix
CCR3 Polyclonal Antibody
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Product Details
CCR3-301AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1-50 on human CCR3 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CCR3 (C-C chemokine receptor type 3) binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1 delta. CCR3 trasnduces a signal by increasing the intracellular calcium ions level. It also serves as an alternative co-receptor with CD4 for HIV-1 infection. Other chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: b-chemokine receptor; C C CKR3; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; CD193; chemokine (C-C motif) receptor 3; eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; MGC102841
Gene Aliases: C C CKR3; CC-CKR-3; CCR3; CD193; CKR 3; CKR3; CMKBR3
UniProt ID: (Human) P51677
Entrez Gene ID: (Human) 1232
positive regulation of endothelial cell proliferation
chemotaxis
inflammatory response
immune response
cellular defense response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
positive regulation of angiogenesis
cell chemotaxis
chemokine-mediated signaling pathway
cellular response to cytokine stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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