Proteintech

CCRL2 Polyclonal Antibody

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CCRL2 Antibody in Western Blot (WB) — Mouse spleen tissue were subjected to SDS PAGE followed by western blot with 13387-1-AP (CCRL2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

CCRL2 Antibody in Flow Cytometry (Flow) — 1X10^6 A431 cells were stained with .2ug CCRL2 antibody (13387-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

Product Details

13387-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CCRL2 Fusion Protein Ag4045 (250-344 aa encoded by BC025717) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.21 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MWAPYNIAF FLSTFKEHFS LSDCKSSYNL DKSVHITKLI ATTHCCINPL LYAFLDGTFS KYLCRCFHLR SNTPLQPRGQ SAQGTSREEP DHSTEV (250-344 aa encoded by BC025717)

Target Information

CCRL2 (C-C chemokine receptor-like 2), also known as chemokine receptor X, human chemokine receptor (HCR), CRAM-A or CRAM-B, is a seven pass transmembrane protein expressed by monocytes, neutrophils, and dendritic cells of immunal tissues (predominanly spleen, fetal liver, bone marrow and lymph node). It shares over 40% homology with other C-C chemokine receptors but does not share the conserved DRY motif which is among the important motifs necessary for signalling and ligand-binding. C-C chemokine receptors are G-protein coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: atypical chemokine receptor 5; C-C chemokine receptor-like 2; chemokine (C-C motif) receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; G-protein coupled beta chemokine receptor; L-CCR; Lipopolysaccharide-inducible C-C chemokine receptor; MGC116710; Putative MCP-1 chemokine receptor

Gene Aliases: 1810047I05Rik; ACKR5; CCR11; CCR6; CCRL2; CKRX; Cmkbr1l2; CRAM; CRAM-A; CRAM-B; E01; HCR; L-CCR; Lccr

UniProt ID: (Human) O00421, (Mouse) O35457

Entrez Gene ID: (Human) 9034, (Mouse) 54199

Function(s)

chemotaxis inflammatory response G-protein coupled receptor signaling pathway chemokine-mediated signaling pathway

Process(es)

chemokine receptor activity chemokine receptor binding CCR chemokine receptor binding