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Proteintech
CCS Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-22802
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCS fusion protein Ag18850
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MASDSGNQG TLCTLEFAVQ MTCQSCVDAV RKSLQGVAGV QDVEVHLEDQ MVLVHTTLPS QEVQALLEGT GRQAVLKGMG SGQLQNLGAA VAILGGPGTV QGVVRFLQLT PERCLIEGTI DGLEPGLHGL HVHQYGDLTN NCNSCGNHFN PDGASHGGPQ DSDRHRGDLG NVRADADGRA IFRMEDEQLK VWDVIGRSLI IDEGEDDLGR GGHPLSKITG NSGERLACGI IARSAGLFQN PKQICSCDGL TIWEERGRPI AGKGRKESAQ PPAHL
Target Information
Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone
Gene Aliases: CCS; Ccsd
UniProt ID: (Human) O14618, (Mouse) Q9WU84
Entrez Gene ID: (Human) 9973, (Mouse) 12460
superoxide dismutase activity
copper ion binding
protein binding
zinc ion binding
protein disulfide oxidoreductase activity
superoxide dismutase copper chaperone activity
cadherin binding involved in cell-cell adhesion
enzyme binding
metal ion binding
oxidoreductase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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