Invitrogen

CD105 Monoclonal Antibody (SN6)

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CD105 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow) — Published figure using CD105 monoclonal antibody (Product # MHCD10500) in Immunocytochemistry and Flow Cytometry

Product Details

MHCD10500

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

Assay-Dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human

Published species

Cat, Human, Sheep

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SN6

Immunogen

Human CD105 (Endoglin)

Conjugate

Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

RRID

AB_10373966

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

Analyte Specific Reagent

Product References

A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies.

Journal of tissue engineering and regenerative medicine

Caminal M,Vélez R,Rabanal RM,Vivas D,Batlle-Morera L,Aguirre M,Barquinero J,García J,Vives J

MHCD10500 was used in flow cytometry to discuss methods to generate ovine mesenchymal stromal cells

Fri Dec 01 00:00:00 EST 2017

Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells. An Intercellular Exchange of Components between Neighboring Cells.

Stem cell reviews and reports

Sanchez V,Villalba N,Fiore L,Luzzani C,Miriuka S,Boveris A,Gelpi RJ,Brusco A,Poderoso JJ

MHCD10500 was used in immunocytochemistry to describe the types, structure, components, dynamics and functionality of the tunneling nanotubes bridging neighboring human umbilical cord mesenchymal stem cells obtained from Wharton's jelly

Tue Aug 01 00:00:00 EDT 2017

Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome.

Stem cell research & therapy

Clark KC,Fierro FA,Ko EM,Walker NJ,Arzi B,Tepper CG,Dahlenburg H,Cicchetto A,Kol A,Marsh L,Murphy WJ,Fazel N,Borjesson DL

MHCD10500 was used in flow cytometry to compare human and feline adipose-derived mesenchymal stem cells

Mon Mar 20 00:00:00 EDT 2017

Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation.

PloS one

Park IS,Chung PS,Ahn JC

MHCD10500 was used in immunohistochemistry to assess the effect of low-level light irradiation prior to transplantation of adipose-derived stromal cell spheroids on a skin wound model

Thu Apr 21 00:00:00 EDT 2016

Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation.

PloS one

Park IS,Chung PS,Ahn JC

MHCD10500 was used in immunohistochemistry to assess the effect of low-level light irradiation prior to transplantation of adipose-derived stromal cell spheroids on a skin wound model

Thu Apr 21 00:00:00 EDT 2016

Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation.

PloS one

Park IS,Chung PS,Ahn JC

MHCD10500 was used in immunohistochemistry to assess the effect of low-level light irradiation prior to transplantation of adipose-derived stromal cell spheroids on a skin wound model

Thu Apr 21 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: CD105; CD105 antigen; Endoglin; ORW

Gene Aliases: END; ENG; HHT1; ORW1

UniProt ID: (Human) P17813

Entrez Gene ID: (Human) 2022

Molecular Function: transmembrane signal receptor

Function(s)

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Process(es)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding

CD105 Monoclonal Antibody (SN6)

Product Details

MHCD10500

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Purification

Storage buffer

Contains

Storage conditions

RRID

Target Information

Bioinformatics

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