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      View (37) other CD105 antibodies

      Invitrogen

      CD105 Monoclonal Antibody (SN6)

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      Catalog #:MHCD10500

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      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) Assay-Dependent
      PUBLISHED APPLICATIONS
      Immunohistochemistry (IHC) See 1 publications below
      Tested Species reactivity Human
      Published species reactivity Human
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone SN6
      Immunogen Human CD105 (Endoglin)
      Conjugate Unconjugated
      Form Liquid
      Purification purified
      Storage buffer PBS
      Contains 0.1% sodium azide
      Storage conditions 4° C, store in dark
      RRID AB_10373966

      Background/Target Information

      CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

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      References (1)

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      Bioinformatics

      Protein Aliases: CD105; CD105 antigen; END; Endoglin; ENG; HHT1; ORW; ORW1

      Gene Aliases: END; ENG; HHT1; ORW1

      UniProt ID: (Human) P17813

      Entrez Gene ID: (Human) 2022

      Molecular Function: TGF-beta receptor cytokine receptor receptor

      Function(s) Blue Arrow Icon
      chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
      Process(es) Blue Arrow Icon
      transmembrane signaling receptor activity
       transforming growth factor beta receptor, cytoplasmic mediator activity
       type II transforming growth factor beta receptor binding
       protein binding
       galactose binding
       glycosaminoglycan binding
       type I transforming growth factor beta receptor binding
       BMP binding
       protein homodimerization activity
       activin binding
       transforming growth factor beta binding

      Suggested Secondary Antibodies

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