Invitrogen

CD105 Monoclonal Antibody (SN6)

1 Published Figure

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CD105 Antibody — Published figure using CD105 monoclonal antibody (Product # MHCD10500)

Product Details

Tested Applications

Dilution

Flow Cytometry (Flow)

Assay-Dependent

Published Applications

Flow Cytometry (Flow)

See 3 publications below

Immunocytochemistry (ICC)

See 1 publication below

Immunohistochemistry (IHC)

See 1 publication below

Immunofluorescence (IF)

See 1 publication below

Product Specifications

Species Reactivity

Human

Published species

Cat, Human, Sheep

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SN6

Immunogen

Human CD105 (Endoglin)

Conjugate

Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

RRID

AB_10373966

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

Bioinformatics

Protein Aliases: CD105; CD105 antigen; END; Endoglin; ENG; HHT1; ORW; ORW1

Gene Aliases: END; ENG; HHT1; ORW1

UniProt ID: (Human) P17813

Entrez Gene ID: (Human) 2022

Molecular Function: TGF-beta receptor cytokine receptor receptor

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Process(es)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding

Suggested Secondary Antibodies

Anti-Mouse Secondary Antibodies (266)
Alexa Fluor® Anti-Mouse Secondary Antibodies (76)
HRP Anti-Mouse Secondary Antibodies (28)