Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunocytochemistry (ICC/IF) |
- | View 2 publications 2 publications |
Flow Cytometry (Flow) |
Assay-Dependent | View 3 publications 3 publications |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Published species |
Cat, Human, Sheep |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
SN6 |
Immunogen |
Human CD105 (Endoglin) |
Conjugate |
Unconjugated
|
Form |
Liquid |
Purification |
purified |
Storage buffer |
PBS |
Contains |
0.1% sodium azide |
Storage conditions |
4° C, store in dark |
RRID |
AB_10373966 |
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Analyte Specific Reagent
Protein Aliases: CD105; CD105 antigen; Endoglin; ORW
Gene Aliases: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
Molecular Function:
transmembrane signal receptor
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