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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human CD105 (Endoglin)|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Analyte Specific Reagent
CD105 antigen, CD105, END, HHT1, ORW, ORW1, ENG
ORW1, END, HHT1
Signal transduction Cell surface receptor mediated signal transduction Receptor protein serine/threonine kinase signaling pathway Cell communication Cell adhesion-mediated signaling Developmental processes Mesoderm development Heart development Angiogenesis Blood circulation and gas exchange Cell adhesion