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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human CD105 (Endoglin)|
|Storage buffer||PBS with 4mg/ml BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Analyte Specific Reagent
Cell surface markers and exogenously induced PpIX in synovial mesenchymal stem cells.
MHCD10505 was used in flow cytometry to identify the cell surface markers in synovial mesenchymal stem cells
|Denkovskij J,Rudys R,Bernotiene E,Minderis M,Bagdonas S,Kirdaite G||Cytometry. Part A : the journal of the International Society for Analytical Cytology (87:1001)||2015|
CD105 antigen, CD105, END, HHT1, ORW, ORW1, ENG
ORW1, END, HHT1
Signal transduction Cell surface receptor mediated signal transduction Receptor protein serine/threonine kinase signaling pathway Cell communication Cell adhesion-mediated signaling Developmental processes Mesoderm development Heart development Angiogenesis Blood circulation and gas exchange Cell adhesion