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Bioss

CD11b, CD11c Polyclonal Antibody

View all (16) CD11b/c antibodies

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Product Details

BS-1014R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:300
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

0.2 µg
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human CD11b.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. CD11b is also a receptor for fibrogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% thymocytes and is commonly used as a microgial marker in nervous tissue. CD11c encodes the integrin alpha X chain protein. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Mutations affecting the CD11b/c gene lead to systemic lupus erythematosus 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; CD11 antigen-like family member C; CD11b; CD11B (p170); CD11bc; CD11c; CD11C (p150) alpha polypeptide; cell surface glycoprotein MAC-1 alpha subunit; Cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component 3 receptor 4 subunit; complement component receptor 3 alpha-a; complement receptor 4; complement receptor type 3; CR-3 alpha chain; CR3A; glycoprotein Mac-1; Integrin alpha M; integrin alpha X; Integrin alpha-M; Integrin alpha-X; integrin aX; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); integrin; protein p150,95; Leu M5; leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion glycoprotein precursor; Leukocyte adhesion receptor MO1; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; MAC-1; Mac-1 alpha; MAC1A; macrophage antigen alpha; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MGC117044; MO1A; myeloid membrane antigen, alpha subunit; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; OX-42; OX42; p150 95 integrin alpha chain; SLEB6; unnamed protein product

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Gene Aliases: AI449405; CD11B; CD11b/CD18; CD11C; CR3; CR3A; Cr4; F730045J24Rik; ITGAM; ITGAX; Ly-40; MAC-1; Mac-1a; MAC1; MAC1A; MO1A; N418; RGD1561123; SLEB6

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UniProt ID: (Human) Q4VAK1, (Human) P20702, (Mouse) Q9QXH4

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Entrez Gene ID: (Human) 3684, (Human) 3687, (Mouse) 16409, (Rat) 25021, (Mouse) 16411, (Rat) 499271

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Function(s)
beta-amyloid binding complement component C3b binding integrin binding protein binding heat shock protein binding signaling receptor activity cargo receptor activity macromolecular complex binding metal ion binding receptor tyrosine kinase binding opsonin binding glycoprotein binding heparin binding heparan sulfate proteoglycan binding protein heterodimerization activity integrin
Process(es)
microglial cell activation immune system process complement receptor mediated signaling pathway response to ischemia receptor-mediated endocytosis phagocytosis, engulfment cell adhesion cell-matrix adhesion integrin-mediated signaling pathway response to mechanical stimulus positive regulation of metabolic process ectodermal cell differentiation forebrain development response to estradiol positive regulation of superoxide anion generation heterotypic cell-cell adhesion positive regulation of neutrophil degranulation innate immune response negative regulation of dopamine metabolic process positive regulation of protein targeting to membrane beta-amyloid clearance cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules response to Gram-positive bacterium complement-mediated synapse pruning vertebrate eye-specific patterning positive regulation of microglial cell mediated cytotoxicity response to curcumin positive regulation of cell proliferation organ morphogenesis positive regulation of gene expression positive regulation of cell migration positive regulation of myelination positive regulation of angiogenesis defense response to virus positive regulation of endothelial tube morphogenesis leukocyte migration involved in inflammatory response leukocyte cell-cell adhesion microglia development single organismal cell-cell adhesion neutrophil chemotaxis cellular extravasation activated T cell proliferation positive regulation of protein targeting to mitochondrion
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