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Invitrogen
CD13 Monoclonal Antibody (R3-63)
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FIGURE: 1 / 8
CD13 Antibody (MA1-33449) in IHC (F)
Immunohistochemistry (Frozen) analysis of CD13 in mouse lymph node tissue using CD13 Monoclonal Antibody (R3-63) (Product # MA1-33449) (Green in A), a CD8 antibody (Red in B). C is the merged image with nuclei counterstained blue using DAPI. Medium power
Product Details
MA1-33449
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
R3-63
Immunogen
Mouse intestinal CD13.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
125 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-33449 detects CD13 from mouse samples.
Target Information
CD13, also known as ANPEP, is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on a wide variety of cell types and tissues. It is prominently found on monocytes and granulocytes in the blood, but not on lymphocytes. Additionally, CD13 is expressed on endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, placenta, and myeloid leukemia cells. As a metalloprotease, CD13 preferentially catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides. It plays a crucial role in various biological processes, including the degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and the adhesion and migration of cells. CD13 is also involved in extracellular matrix degradation, signal transduction, inflammatory responses, regulation of intercellular contact, cell motility, and vascularization. In the context of disease, CD13 is associated with the protection of leukemic cells against apoptosis and is linked to a poor prognosis in carcinomas. Furthermore, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; aminopeptidase N/CD13; AP-M; AP-N; CD13; h AP-N; Membrane protein p161; Microsomal aminopeptidase
Gene Aliases: Anpep; AP-M; AP-N; Apn; Cd13; Lap-1; Lap1; P150
UniProt ID: (Mouse) P97449
Entrez Gene ID: (Mouse) 16790
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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